A simple score that uses AST and platelets to estimate liver scarring risk.
The APRI is a calculated value, not a separate blood test. APRI stands for AST to Platelet Ratio Index. It is calculated as AST divided by its upper limit of normal, divided by the platelet count (in 10^9/L), then multiplied by 100. It is a non-invasive estimate of liver scarring.
APRI is mainly used to screen for significant fibrosis and cirrhosis, especially in viral hepatitis. A low value makes meaningful scarring unlikely, while a high value makes it more likely. It does not replace imaging or a liver specialist and is weakest at telling apart the middle stages.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
These are interpretive cut-offs from research, not lab ranges, and performance varies by population.
| APRI score | Interpretation |
|---|---|
| Below 0.5 | Significant fibrosis unlikely (good rule-out) |
| Above 1.5 | Significant fibrosis likely |
| Above 1.0 | Suggestive of cirrhosis |
| Above 2.0 | More specific for cirrhosis |
Source: University of Washington Hepatitis C Online, APRI calculator.
Anything that changes AST or platelets affects APRI: recent alcohol, muscle injury or exercise (raises AST), and conditions that lower platelets for non-liver reasons. The AST upper limit of normal used in the formula varies by laboratory, which shifts the score.
Best read with its components, AST and platelet count, and alongside FIB-4, GGT, and liver imaging where indicated.
What does an APRI result mean? A higher score suggests a greater chance of significant liver scarring; a lower score suggests less. It is one part of the overall assessment.
Do I need to fast for APRI? No. Fasting is not required for AST or platelet count.
What can affect my APRI? Recent intense exercise, alcohol, some medicines or supplements, pregnancy, and acute illness can change AST or platelets.
How often should I check APRI? It depends on your condition and risk factors. Many people repeat it periodically to track changes.
How long do results take? Results are usually ready in about 7 days.
What should I discuss with my clinician? Share your medicines, alcohol use, viral hepatitis history, and metabolic risks. Ask if imaging or other scores are recommended.
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