The free fraction of PSA, used to refine prostate cancer risk.
Free PSA is the portion of prostate-specific antigen that circulates in the blood on its own, not bound to other proteins. It is measured together with total PSA.
On its own, free PSA is most useful as a fraction of the total. The relationship between the two helps tell apart benign and more concerning causes of a raised PSA.
Free PSA is mainly used when total PSA sits in a borderline range, often between 4 and 10 µg/L. A higher proportion of free PSA points more toward benign prostate enlargement, while a lower proportion raises the chance of cancer.
By itself, a free PSA number is hard to interpret. It is the free-to-total ratio, calculated from this result and total PSA, that adds value. Your doctor uses it as one input, never as a yes or no answer.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
Free PSA is interpreted as a percentage of total PSA rather than as a fixed cutoff. Ranges are guidance only.
| Measure | Note |
|---|---|
| Free PSA | Reported in µg/L, used to calculate the free/total ratio |
Aligned to German laboratory practice (DGKL). Interpret with total PSA and your doctor.
Free PSA is less stable than total PSA and the sample should be handled and frozen promptly, as delays can lower it. Recent ejaculation, cycling, a prostate exam, or infection can shift PSA values. Different assays are not interchangeable.
Always read together with total PSA and the free/total PSA ratio.
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