Globulin is a group of blood proteins that reflect immune activity and overall protein balance.
Globulins are a group of blood proteins that include antibodies, transport proteins, and clotting factors. They are not measured directly but worked out by subtracting albumin from total protein.
This group plays a central role in your immune defence and in moving iron, hormones, and other substances around the body.
A high globulin can reflect chronic infection, ongoing inflammation, autoimmune conditions, or, less often, a problem with antibody producing cells. A low globulin can mean reduced antibody production or protein loss.
Because globulin is calculated, it is always read with albumin and total protein. The albumin to globulin ratio is often the most useful part of the result.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
| Group | Serum globulin (SI) |
| Adults | ~23 to 35 g/L |
| Albumin to globulin ratio | ~1.1 to 2.5 |
Ranges are guidance only and vary by lab and assay, and globulin is a calculated value. Read your result against your own lab's reference interval, in line with DGKL practice.
Because globulin is total protein minus albumin, anything that affects either of those affects globulin. Dehydration, inflammation, infection, and pregnancy shift the result. A tourniquet left on too long can raise it.
Best read with albumin and total protein (and the albumin to globulin ratio), and with protein electrophoresis when an immune protein problem is suspected.
What does a high or low globulin mean? High often reflects immune activity or dehydration. Low can suggest protein loss, reduced production, or overhydration. Trends guide context.
Do I need to fast for this test? No. Fasting is not required for a standard globulin measurement.
What can affect my result? Hydration, recent illness, exercise, IV fluids, hormones, steroids, and IVIG can change values. Consistent timing helps when tracking trends.
How often should I test globulin? Most people test only when a clinician is evaluating symptoms or monitoring a condition. If results change, your clinician may recheck in weeks to months.
How long do results take? Results are usually ready in about 7 days.
What should I discuss with my clinician? Review hydration, medicines, and supplements. Ask whether to check albumin, total protein, or do protein electrophoresis for clarity.
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