A confirmatory antibody test for syphilis infection.
This test screens for syphilis by looking for both IgG and IgM antibodies against Treponema pallidum, the bacterium that causes the infection. It reports a simple qualitative result: antibodies present or not.
IgM tends to appear early in an infection and IgG later, so checking both gives a broad window for detecting exposure.
Syphilis can be treated easily with antibiotics once it is found, but it can stay silent and cause harm if missed. A combined IgG and IgM screen is a sensitive way to detect exposure across different stages of infection.
A non-reactive result is reassuring. A reactive result needs confirmatory testing to establish whether the infection is active and at what stage.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
This test is reported qualitatively. The expected result for someone without syphilis is Negative or Non-reactive.
| Result | Meaning |
|---|---|
| Non-reactive (negative) | No treponemal IgG or IgM antibodies detected |
| Reactive | Needs confirmatory testing before any diagnosis |
A reactive screen is not a diagnosis. Cutoffs are set by the assay and may vary by laboratory.
You learn whether treponemal IgG or IgM antibodies are present. A negative result means none were found at this time. A reactive result leads to confirmatory testing, including non-treponemal tests, to determine whether the infection is current or past.
Antibodies take time to rise, so very early infection can be missed. Treponemal antibodies often persist for life after treatment, so a reactive result does not by itself mean active disease. Rare false-reactive results are possible. Fasting does not affect the result.
Read with confirmatory non-treponemal tests such as RPR or VDRL, with TPPA, and with your clinical and exposure history.
One annual membership, 100+ biomarkers, every result explained in plain language with a personalized action plan and concierge guidance.
