A research-based ratio linking inflammation (neutrophils) with heart-protective HDL to add context to overall risk.
The neutrophil to HDL cholesterol ratio (NHR) is a calculated value, not a separate blood test. It compares the neutrophil count, a white blood cell involved in inflammation, with HDL cholesterol, which has anti-inflammatory effects.
The formula is: neutrophil count ÷ HDL cholesterol, using the units reported by the lab.
Neutrophils drive inflammation, while HDL helps counter it. Combining them into one ratio aims to capture the balance between pro-inflammatory and protective forces, and NHR has been studied as a marker of cardiovascular and metabolic risk.
A higher ratio reflects more inflammatory activity relative to protection and has been associated with greater cardiometabolic risk in research. A lower ratio is more favourable.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
There is no firmly established healthy reference range for NHR. It is used in research as a relative risk marker, where higher values track with greater cardiovascular and inflammatory risk. Interpret as a trend with a clinician rather than against a fixed cutoff.
Neutrophil count rises with infection, stress and exercise and varies through the day, so recent illness can inflate the ratio. HDL is affected by alcohol, smoking and some medications. The ratio is best measured when you are well and not acutely unwell.
Read with its components, neutrophil count and HDL cholesterol, and alongside the full blood count, lipid panel and hs-CRP.
What does a high or low NHR mean? A higher ratio may point to more inflammation or lower HDL protection. A lower ratio may align with a more favorable pattern, but context matters.
Do I need to fast for this test? Fasting is not required. Non‑fasting HDL and a routine blood count are generally acceptable.
How often should I check it? Many people repeat it with routine blood work or after lifestyle changes. Discuss timing with your clinician if you’ve been ill recently.
What can affect my result? Recent infections, steroids, smoking, heavy alcohol, hard workouts, dehydration, and pregnancy can shift values. Share all medicines and supplements.
How long until results are ready? Results are usually ready in about 7 days.
What should I discuss with my clinician? Review trends alongside your CBC, lipid panel, blood pressure, and history. Ask whether any changes are needed or if a recheck is best.
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