An antibody linked to autoimmune thyroid conditions such as Hashimoto's and Graves'.
Thyroglobulin antibodies, or TgAb, are immune proteins that target thyroglobulin, a protein your thyroid uses to make thyroid hormones. Finding them in your blood suggests your immune system is reacting against your own thyroid tissue.
Testing for TgAb helps identify autoimmune thyroid disease, especially Hashimoto thyroiditis. The antibodies also matter when monitoring thyroid cancer, because they can interfere with thyroglobulin tumour tracking.
A positive result supports an autoimmune cause of thyroid problems. Many healthy people, more often women, carry low levels without disease, so the result is read alongside thyroid hormone tests.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
Typical adult serum cut-off, guidance only and assay dependent. Each lab sets its own threshold, so always use the range printed with your result.
| Measure | Reference range |
|---|---|
| Thyroglobulin antibodies | Negative, below the lab cut-off (often under 40 to 115 IU/mL) |
Source: LOINC 8098-6. Confirm against your own laboratory's range.
Your result shows whether your immune system is producing antibodies against thyroid tissue. Combined with TSH and free T4, it helps explain an underactive thyroid and flags a higher chance of future thyroid problems.
Results differ between assays, so values are not directly comparable across labs. Low positive levels can occur in people without thyroid disease. High-dose biotin supplements can interfere with certain assays.
Best read together with TPO antibodies, TSH, and free T4, and with thyroglobulin itself when thyroid cancer is being monitored.
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