An antibody that signals autoimmune thyroid disease, most often Hashimoto's.
Thyroid peroxidase antibodies, or TPO antibodies, are immune proteins that target thyroid peroxidase, an enzyme your thyroid needs to make hormones. Their presence is a sign that the immune system is reacting against the thyroid.
TPO antibodies are the most useful marker for autoimmune thyroid disease. They are found in most people with Hashimoto thyroiditis and many with Graves disease.
A positive result supports an autoimmune cause when thyroid hormones are out of range, and it signals a higher chance of developing an underactive thyroid over time, including during and after pregnancy.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
Typical adult serum cut-off, guidance only and assay dependent. Each lab sets its own threshold, so always use the range printed with your result.
| Measure | Reference range |
|---|---|
| TPO antibodies | Negative, below the lab cut-off (often under 34 to 60 IU/mL) |
Source: LOINC 8099-4. Confirm against your own laboratory's range.
Your result shows whether antibodies are attacking your thyroid. Read with TSH and free T4, it helps confirm an autoimmune cause and estimate your future risk of thyroid problems, which can guide how often you retest.
Results differ between assays, so values are not directly comparable across labs. Low positive levels can occur in healthy people, more often women and with age. High-dose biotin supplements can interfere with certain assays.
Best read together with TSH, free T4, and thyroglobulin antibodies (TgAb).
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