The main protein in HDL, the protective cholesterol particle.
Apolipoprotein A1, or ApoA1, is the main protein in HDL, the lipoprotein often called "good" cholesterol. It helps HDL pull excess cholesterol out of cells and artery walls and carry it back to the liver for removal, a process called reverse cholesterol transport.
Measuring ApoA1 reflects how well this protective HDL system is built, since each HDL particle carries ApoA1.
Higher ApoA1 generally points to a stronger protective lipid profile, while low ApoA1 is linked to lower HDL function and higher cardiovascular risk. It is sometimes used together with ApoB as a ratio, where a favorable ApoB to ApoA1 balance suggests lower risk.
Low ApoA1 can also appear in some inherited conditions and in states of inflammation or poor metabolic health.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
Adult guidance values (guidance only, vary by lab):
| Sex | Apolipoprotein A1 |
|---|---|
| Women | roughly 1.25 to 2.15 g/L |
| Men | roughly 1.10 to 2.05 g/L |
Higher values are generally more favorable. Ranges differ between assays.
You learn how strong your protective HDL system is and, when read with ApoB, how the balance of harmful and protective particles looks. This supports a personalized action plan around diet, exercise, and metabolic health.
Acute illness, inflammation, and pregnancy can shift the value. Alcohol and some medications, including statins and oestrogens, can raise ApoA1. Very high triglycerides can affect some assays.
Best read alongside HDL cholesterol, apolipoprotein B, and the ApoB to ApoA1 ratio.
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