1-Methylhistidine

A metabolite linked to dietary protein and muscle turnover.

Last reviewedJune 16, 2026
Plasma
sample type
~5 mL
blood needed
~7 days
results in app
Morning, fasting
best timing
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In short

1-Methylhistidine is a modified amino acid. It comes mainly from anserine, a compound found in the muscle of animals such as poultry and fish. When you eat these foods, anserine is broken down and 1-methylhistidine is released into the blood and passed out in urine.

Comprehensive Health Check
Reviewed against DGKL reference practice.
Why it matters

Why test this?

It is measured as part of a plasma amino acid profile, usually as a marker of recent meat or fish intake rather than of a disease. A high level most often reflects diet. It can occasionally help explain an unusual pattern on the wider amino acid panel.

Reference ranges

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

GroupAdult fasting plasma range
Adults0 to 22 µmol/L

Amino acid ranges vary by laboratory and method. They are best read as part of the full plasma amino acid profile, not in isolation.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.
What you'll learn

What insights will this test give you?

  • A picture of recent dietary intake of meat and fish, which can affect other readings.
  • Context for interpreting the rest of your amino acid profile.
  • Reassurance that a raised value is usually diet related, not a sign of illness.
What affects your level

What can affect this result?

What can skew the result

Recent intake of meat or fish, overall protein intake, fasting state, and time of day all affect the result. A fasting morning sample gives the most reliable reading.

Best interpreted with

Read as part of the full plasma amino acid profile.

How testing works

How is this tested?

Sample
Plasma
Blood needed
~5 mL
Method
Ion-exchange chromatography or LC-MS/MS
Best timing
Morning, fasting
FAQ

Common questions

Related biomarkers

Markers usually read alongside this one

On this page
Why testReference rangesWhat you'll learnWhat affects itHow testing worksSourcesFAQ
✦ Privately insured? German PKV usually reimburses.

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