Histidine

An essential amino acid and precursor to histamine.

Last reviewedJune 16, 2026
Plasma
sample type
~5 mL
blood needed
~7 days
results in app
Morning, fasting
best timing
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In short

Histidine is an essential amino acid, which means your body cannot make it and you have to get it from food. It is a building block for proteins and a precursor of histamine, a molecule involved in immune responses, stomach acid release and nerve signalling. Histidine also helps form carnosine in muscle.

Comprehensive Health Check
Reviewed against DGKL reference practice.
Why it matters

Why test this?

Measuring plasma histidine is part of a full amino acid profile that screens how well your body takes in and processes protein. Low levels can reflect poor intake, certain inflammatory states or pregnancy, while high levels are uncommon and usually relate to inherited metabolic conditions. The number is most useful read alongside the other amino acids rather than on its own.

Reference ranges

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

Adult fasting plasma, guidance only:

AnalyteTypical adult range (µmol/L)
Histidine50 to 106

Ranges vary by laboratory and assay and are read as part of the full amino acid profile.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.
What you'll learn

What insights will this test give you?

  • Whether your histidine sits in the usual adult fasting range.
  • A piece of the wider picture of how your body handles protein and amino acids.
  • A signal, in rare cases, that points toward an inherited metabolic pattern worth a closer look.
What affects your level

What can affect this result?

What can skew the result

Results are affected by recent diet, recent protein intake, fasting state and the time of day the sample is taken.

Best interpreted with

Read as part of the full plasma amino acid profile.

How testing works

How is this tested?

Sample
Plasma
Blood needed
~5 mL
Method
Ion-exchange chromatography or LC-MS/MS
Best timing
Morning, fasting
FAQ

Common questions

Related biomarkers

Markers usually read alongside this one

On this page
Why testReference rangesWhat you'll learnWhat affects itHow testing worksSourcesFAQ
✦ Privately insured? German PKV usually reimburses.

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