Hydroxyproline

An amino acid that is a building block of collagen.

Last reviewedJune 16, 2026
Plasma
sample type
~5 mL
blood needed
~7 days
results in app
Morning, fasting
best timing
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In short

Hydroxyproline is a modified amino acid made after the amino acid proline is built into collagen. It gives collagen its stability. Free hydroxyproline in plasma comes mainly from collagen breakdown, so it tracks connective tissue and bone turnover.

Comprehensive Health Check
Reviewed against DGKL reference practice.
Why it matters

Why test this?

Hydroxyproline is reported as part of a full amino acid profile. Levels can shift with growth, bone turnover and collagen breakdown. As a single value it is a supporting clue rather than a diagnosis, so it is read alongside the rest of the profile.

Reference ranges

What is a normal result?

Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.

Adult fasting plasma, guidance only:

AnalyteTypical adult range (µmol/L)
Hydroxyproline4 to 25

Ranges vary by laboratory and assay and are read as part of the full amino acid profile.

Ranges are guidance and vary by lab and assay, aligned with DGKL practice. Always read your result against your own lab's reference interval.
What you'll learn

What insights will this test give you?

  • Whether hydroxyproline sits in the usual adult fasting range.
  • A data point linked to collagen and bone turnover.
  • Context for the other amino acids in your profile.
What affects your level

What can affect this result?

What can skew the result

Results are affected by recent diet, recent protein intake, fasting state and the time of day the sample is taken.

Best interpreted with

Read as part of the full plasma amino acid profile.

How testing works

How is this tested?

Sample
Plasma
Blood needed
~5 mL
Method
Ion-exchange chromatography or LC-MS/MS
Best timing
Morning, fasting
FAQ

Common questions

Related biomarkers

Markers usually read alongside this one

On this page
Why testReference rangesWhat you'll learnWhat affects itHow testing worksSourcesFAQ
✦ Privately insured? German PKV usually reimburses.

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