A gene variant affecting how quickly you metabolise caffeine and some drugs.
CYP1A2 is a gene that codes for cytochrome P450 1A2, a liver enzyme. It is the main enzyme that breaks down caffeine, and it also processes several medications and other compounds.
How active this enzyme is varies from person to person, partly because of common genetic variants. This is why two people can drink the same coffee and feel very different effects.
The well-studied variant rs762551 (CYP1A2*1F) affects how fast you clear caffeine. People with the AA genotype tend to be fast metabolizers, while those carrying a C allele (AC or CC) tend to be slower. Slow metabolizers may feel caffeine more strongly and for longer, which can affect sleep and how coffee sits with them.
Knowing your type helps you make sense of your caffeine response. It is a predisposition, not a diagnosis.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
This test reports a genotype, not a numeric value. Results are given as the alleles you carry at rs762551.
| Genotype | General effect |
|---|---|
| AA | Fast metabolizer, clears caffeine quickly |
| AC | Intermediate metabolizer |
| CC | Slow metabolizer, caffeine lingers longer |
Interpretation is general guidance. Genetics are a predisposition, not a diagnosis.
Genetics are stable and do not change over time. The result reflects a predisposition for caffeine metabolism, not a diagnosis. Habits like smoking can also induce this enzyme regardless of genotype.
Best read alongside your caffeine intake, sleep quality and, where relevant, cardiovascular markers.
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