A gene variant affecting how your body activates vitamin D.
CYP2R1 is a gene that codes for vitamin D 25-hydroxylase, the main liver enzyme that performs the first activation step for vitamin D. It converts vitamin D into 25-hydroxyvitamin D, the form measured in a standard vitamin D blood test.
Because this enzyme drives a key step in vitamin D activation, common variants in the gene can influence the vitamin D level your body maintains.
The variant rs10741657 is linked to differences in 25-hydroxyvitamin D levels. Carriers of certain alleles tend to run lower vitamin D, even with reasonable sun exposure and diet. Looking at this gene helps explain why some people struggle to keep vitamin D up and may need more attention to intake.
A variant here is a predisposition, not a diagnosis, and is best read together with your actual vitamin D level.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
This test reports a genotype, not a numeric value. Results are given as the alleles you carry at rs10741657.
| Genotype | General effect |
|---|---|
| Common (favourable) | Typical vitamin D activation |
| One variant allele | Tendency toward lower 25(OH)D |
| Two variant alleles | Stronger tendency toward lower 25(OH)D |
Interpretation is general guidance. Genetics are a predisposition, not a diagnosis.
Genetics are stable and do not change over time. The result is a predisposition for vitamin D activation, not a diagnosis. Sun exposure, supplementation and body weight all affect actual vitamin D levels.
Best read alongside your 25-hydroxyvitamin D level, and where relevant calcium and parathyroid hormone.
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