A gene variant involved in folate and one-carbon metabolism.
MTHFD1 is a gene that codes for an enzyme with three jobs in one-carbon metabolism, the pathway that handles folate and B vitamins. It helps interconvert the folate forms the body uses to build DNA and to recycle homocysteine.
Because folate sits at the centre of this pathway, variants in MTHFD1 can subtly influence how efficiently the body uses B vitamins.
Common MTHFD1 variants, such as G1958A (rs2236225), can change enzyme efficiency and have been studied in relation to folate status, homocysteine and pregnancy outcomes. Looking at this gene adds context to how your body manages folate alongside other one-carbon genes like MTHFR.
A variant here is a predisposition, not a diagnosis, and is most useful read with folate and homocysteine.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
This test reports a genotype, not a numeric value. Results are given as the alleles you carry, commonly at rs2236225 (G1958A).
| Genotype | General effect |
|---|---|
| Common (wild type) | Typical folate handling |
| One variant allele | Slightly altered efficiency |
| Two variant alleles | More noticeable shift in efficiency |
Interpretation is general guidance. Genetics are a predisposition, not a diagnosis.
Genetics are stable and do not change over time. The result is a predisposition for folate handling, not a diagnosis. Actual folate status depends heavily on diet and supplementation.
Best read alongside homocysteine, folate and vitamin B12, and other one-carbon genes such as MTHFR, MTR and MTRR.
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