A gene variant affecting vitamin B12-dependent methylation.
MTR is a gene that codes for methionine synthase, an enzyme that uses vitamin B12 to recycle homocysteine back into methionine. This step is essential for methylation and for keeping homocysteine in a healthy range.
Because the enzyme depends on B12, variants in MTR are studied alongside B12 and folate status.
The common variant A2756G (rs1805087) can subtly change enzyme activity and has been studied in relation to homocysteine and folate. Looking at this gene adds context to your B vitamin picture, especially when read with MTHFR and MTRR.
A variant here is a predisposition, not a diagnosis, and is most useful read with homocysteine and B12.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
This test reports a genotype, not a numeric value. Results are given as the alleles you carry at rs1805087 (A2756G).
| Genotype | General effect |
|---|---|
| AA | Typical methionine synthase activity |
| AG | Slightly altered activity |
| GG | More noticeable shift in activity |
Interpretation is general guidance. Genetics are a predisposition, not a diagnosis.
Genetics are stable and do not change over time. The result is a predisposition, not a diagnosis. Vitamin B12 and folate intake strongly influence actual homocysteine.
Best read alongside homocysteine, vitamin B12 and folate, and the related genes MTHFR, MTRR and MTHFD1.
One annual membership, 100+ biomarkers, every result explained in plain language with a personalized action plan and concierge guidance.
