A gene variant affecting how your body recycles vitamin B12 for methylation.
MTRR is a gene that codes for methionine synthase reductase, the enzyme that keeps methionine synthase (MTR) active by regenerating its vitamin B12 cofactor. In short, MTRR supports the enzyme that recycles homocysteine.
Because it works hand in hand with MTR and B12, variants in MTRR are studied alongside folate and homocysteine.
The common variant A66G (rs1801394) can reduce how efficiently the enzyme reactivates its B12 partner and has been studied in relation to homocysteine, folate status and pregnancy. Looking at this gene rounds out the one-carbon picture alongside MTHFR and MTR.
A variant here is a predisposition, not a diagnosis.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
This test reports a genotype, not a numeric value. Results are given as the alleles you carry at rs1801394 (A66G).
| Genotype | General effect |
|---|---|
| AA | Typical activity |
| AG | Slightly reduced efficiency |
| GG | More noticeable reduction in efficiency |
Interpretation is general guidance. Genetics are a predisposition, not a diagnosis.
Genetics are stable and do not change over time. The result is a predisposition, not a diagnosis. B12 and folate intake strongly shape actual homocysteine.
Best read alongside homocysteine, vitamin B12 and folate, and the related genes MTHFR, MTR and MTHFD1.
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