A common gene variant affecting how your body processes folate.
MTHFR is a gene that codes for methylenetetrahydrofolate reductase, an enzyme central to the folate cycle. It converts folate into 5-methyltetrahydrofolate, the active form your body uses to recycle homocysteine and support methylation.
This is one of the most studied genes in nutrition because common variants reduce how well the enzyme works.
The main variants are C677T (rs1801133) and A1298C (rs1801131). With one copy of the 677T allele, enzyme activity drops to around two thirds; with two copies (TT) it can fall to roughly a quarter. This can raise homocysteine and increase folate needs. Knowing your genotype helps you understand your homocysteine result and folate strategy.
A variant here is a predisposition, not a diagnosis.
Aniva reads your result against research-backed ranges, not just the lab's wide normal. The reference shown below is specific to this biomarker.
This test reports a genotype, not a numeric value. Results are given as the alleles you carry at C677T and A1298C.
| Genotype (C677T) | General effect |
|---|---|
| CC | Typical enzyme activity |
| CT | Activity reduced to about two thirds |
| TT | Activity reduced to about one quarter, higher folate need |
Interpretation is general guidance. Genetics are a predisposition, not a diagnosis.
Genetics are stable and do not change over time. The result is a predisposition, not a diagnosis. Many people with a variant have normal homocysteine when folate intake is adequate.
Best read alongside homocysteine, folate and vitamin B12, and the related genes MTR, MTRR and MTHFD1.
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